On these cells, ACTH also has a trophic effect. 3.9 Control over the production of adrenal steroidsīy increasing intracellular cAMP, ACTH increases glucocorticoid and androgen synthesis in the zonafasciculata and zonareticularis of the adrenal cortex (cAMPactivates protein kinase A, which phosphorylates proteins that regulate steroidogenesis).
